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Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders.

Abstract:

By impairing both function and survival, the severe reduction in oxygen availability associated with high-altitude environments is likely to act as an agent of natural selection. We used genomic and candidate gene approaches to search for evidence of such genetic selection. First, a genome-wide allelic differentiation scan (GWADS) comparing indigenous highlanders of the Tibetan Plateau (3,200-3,500 m) with closely related lowland Han revealed a genome-wide significant divergence across eight ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1002443107

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
107
Issue:
25
Pages:
11459-11464
Publication date:
2010-06-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
65308
Language:
English
Keywords:
Pubs id:
pubs:65308
UUID:
uuid:a1a419e0-21b8-4232-821f-fc60cadc028d
Local pid:
pubs:65308
Deposit date:
2012-12-19

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