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Examining the conservation of kinks in alpha helices

Abstract:

Kinks are a structural feature of alpha-helices and many are known to have functional roles. Kinks have previously tended to be defined in a binary fashion. In this paper we have deliberately moved towards defining them on a continuum, which given the unimodal distribution of kink angles is a better description. From this perspective, we examine the conservation of kinks in proteins. We find that kink angles are not generally a conserved property of homologs, pointing either to their not bein...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0157553

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More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Societies, Other & Subsidiary Companies
Department:
Kellogg College
Oxford college:
Kellogg College
Role:
Author
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Funding agency for:
Wilman, H
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
11
Issue:
6
Article number:
e0157553
Publication date:
2016-06-01
Acceptance date:
2016-06-01
DOI:
ISSN:
1932-6203
Source identifiers:
628916
Language:
English
Keywords:
Pubs id:
pubs:628916
UUID:
uuid:a0206df2-afa2-4de0-acbe-830c089b387d
Local pid:
pubs:628916
Deposit date:
2016-08-11

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