Journal article
Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study
- Abstract:
-
Background Up to 70% of patients with primary biliary cholangitis develop pruritus (itch) during the course of their disease. Treatment of pruritus in primary biliary cholangitis is challenging and novel therapies are needed. Ursodeoxycholic acid, the standard first-line treatment for primary biliary cholangitis, is largely ineffective for pruritus. We investigated the efficacy and safety of GSK2330672, a selective inhibitor of human ileal bile acid transporter (IBAT), in ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1016/s0140-6736(17)30319-7
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Lancet Journal website
- Volume:
- 389
- Issue:
- 10074
- Pages:
- 1114-1123
- Publication date:
- 2017-03-18
- DOI:
- EISSN:
-
1474-547X
- ISSN:
-
0140-6736
- Pmid:
-
28187915
- Source identifiers:
-
1033428
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1033428
- UUID:
-
uuid:9f1d63cd-97a0-46e6-a4ab-7588b498e49b
- Local pid:
- pubs:1033428
- Deposit date:
- 2019-07-18
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Elsevier Ltd.
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