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Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study

Abstract:

Background Up to 70% of patients with primary biliary cholangitis develop pruritus (itch) during the course of their disease. Treatment of pruritus in primary biliary cholangitis is challenging and novel therapies are needed. Ursodeoxycholic acid, the standard first-line treatment for primary biliary cholangitis, is largely ineffective for pruritus. We investigated the efficacy and safety of GSK2330672, a selective inhibitor of human ileal bile acid transporter (IBAT), in ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-0804-5743
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Journal website
Volume:
389
Issue:
10074
Pages:
1114-1123
Publication date:
2017-03-18
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Pmid:
28187915
Source identifiers:
1033428
Language:
English
Keywords:
Pubs id:
pubs:1033428
UUID:
uuid:9f1d63cd-97a0-46e6-a4ab-7588b498e49b
Local pid:
pubs:1033428
Deposit date:
2019-07-18

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