Thesis
Developing gene knockdown-replacement therapies for spinocerebellar ataxia type 7
- Abstract:
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For many dominant diseases, conventional treatment options are limited. This makes them attractive candidates for gene therapy, which may be directed to specifically silence a disease-causing allele. However, many mutations are not easily amenable to this technique, including nucleotide repeat expansions, which cause numerous neurodegenerative diseases such as Huntington’s disease and several Spinocerebellar Ataxias. Combined gene knockdown and replacement (K&R;) may present a more pra...
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Funding
+ John Fell Fund Oxford University Press, Engineering and Physical Sciences Research Council (EPSRC)
More from this funder
Funding agency for:
Curtis, H
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:9e0570b6-f811-473a-a007-185fc8c77fc6
- Local pid:
- ora:10243
- Deposit date:
- 2015-02-27
Terms of use
- Copyright holder:
- Helen Curtis
- Copyright date:
- 2014
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