Journal article
A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory
- Abstract:
-
A protective vaccine against hepatitis C virus (HCV) remains an unmet clinical need. HCV infects millions of people worldwide and is a leading cause of liver cirrhosis and hepatocellular cancer. Animal challenge experiments, immunogenetics studies, and assessment of host immunity during acute infection highlight the critical role that effective T cell immunity plays in viral control. In this first-in-man study, we have induced antiviral immunity with functional characteristics analogous to th...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1126/scitranslmed.3009185
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Authors
Funding
Department of Health
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Medical Research Council
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Wellcome Trust
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Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Translational Medicine Journal website
- Volume:
- 6
- Issue:
- 261
- Article number:
- 261ra153
- Publication date:
- 2014-11-05
- DOI:
- EISSN:
-
1946-6242
- ISSN:
-
1946-6234
- Pmid:
-
25378645
- Source identifiers:
-
489770
Item Description
- Language:
- English
- Pubs id:
-
pubs:489770
- UUID:
-
uuid:9df107ca-eb81-48ef-86c8-0bb16f47e1c1
- Local pid:
- pubs:489770
- Deposit date:
- 2016-08-11
Terms of use
- Copyright holder:
- American Association for the Advancement of Science
- Copyright date:
- 2014
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