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Journal article

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

Abstract:

A protective vaccine against hepatitis C virus (HCV) remains an unmet clinical need. HCV infects millions of people worldwide and is a leading cause of liver cirrhosis and hepatocellular cancer. Animal challenge experiments, immunogenetics studies, and assessment of host immunity during acute infection highlight the critical role that effective T cell immunity plays in viral control. In this first-in-man study, we have induced antiviral immunity with functional characteristics analogous to th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Department of Health More from this funder
Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Translational Medicine Journal website
Volume:
6
Issue:
261
Article number:
261ra153
Publication date:
2014-11-05
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
Pmid:
25378645
Source identifiers:
489770
Language:
English
Pubs id:
pubs:489770
UUID:
uuid:9df107ca-eb81-48ef-86c8-0bb16f47e1c1
Local pid:
pubs:489770
Deposit date:
2016-08-11

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