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Safety and immunogenicity of a heterologous prime-boost Ebola virus vaccine regimen in healthy adults in the United Kingdom and Senegal

Abstract:
Background The 2014 West African outbreak of Ebola virus disease highlighted the urgent need to develop an effective Ebola vaccine. Methods We undertook two Phase I studies assessing safety and immunogenicity of the viral vector MVA-EBO-Z, manufactured rapidly on a new duck cell line either alone or in a heterologous prime-boost regimen with ChAd3-EBO-Z followed by MVA-EBO-Z. Adult volunteers in the UK (n = 38) and Senegal (n=40) were vaccinated and an accel... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jiy639

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Oxford college:
St Cross College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Medical Research Council More from this funder
Wellcome Trust More from this funder
Department for International Development More from this funder
National Institute for Health Research More from this funder
European Commission More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
219
Issue:
8
Pages:
1187–1197
Publication date:
2018-11-08
Acceptance date:
2018-10-30
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Keywords:
Pubs id:
pubs:936821
UUID:
uuid:9db12d3e-9bd4-4267-a266-db473d003d13
Local pid:
pubs:936821
Deposit date:
2018-11-03

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