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Conference item

Improved prediction of fracture risk leveraging a genome-wide polygenic risk score

Abstract:

Background: Accurately quantifying the risk of osteoporotic fracture is important for directing appropriate clinical interventions. While skeletal measures such as heel quantitative speed of sound (SOS) and dual-energy X-ray absorptiometry bone mineral density are able to predict the risk of osteoporotic fracture, the utility of such measurements is subject to the availability of equipment and human resources. Using data from 341,449 individuals of white British ancestry, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13073-021-00838-6

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0002-9170-8447
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Publisher:
BioMed Central Publisher's website
Journal:
Genome medicine Journal website
Volume:
13
Issue:
1
Article number:
16
Host title:
GENOME MEDICINE
Publication date:
2021-02-03
Acceptance date:
2021-01-22
DOI:
EISSN:
1523-4681
ISSN:
1756-994X
Pmid:
33536041
Language:
English
Keywords:
Pubs id:
1153915
Local pid:
pubs:1153915
Deposit date:
2021-10-21

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