Journal article
Microbubbles, nanodroplets and gas-stabilizing solid particles for ultrasound-mediated extravasation of unencapsulated drugs: an exposure parameter optimization study.
- Abstract:
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Ultrasound-induced cavitation has been proposed as a strategy to tackle the challenge of inadequate extravasation, penetration and distribution of therapeutics into tumours. Here, the ability of microbubbles, droplets and solid gas-trapping particles to facilitate mass transport and extravasation of a model therapeutic agent following ultrasound-induced cavitation is investigated. Significant extravasation and penetration depths on the order of millimetres are achieved with all three agents, ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Accepted manuscript, pdf, 275.8KB)
-
- Publisher copy:
- 10.1016/j.ultrasmedbio.2018.10.033
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Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Ultrasound in Medicine and Biology Journal website
- Volume:
- 45
- Issue:
- 4
- Pages:
- 954-967
- Publication date:
- 2019-01-14
- Acceptance date:
- 2018-10-31
- DOI:
- EISSN:
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1879-291X
- ISSN:
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0301-5629
- Pmid:
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30655109
- Source identifiers:
-
963848
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:963848
- UUID:
-
uuid:9cd071d7-aac2-45e6-99a0-4ea4a6c881a5
- Local pid:
- pubs:963848
- Deposit date:
- 2019-02-15
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2019
- Notes:
- © 2019 Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine and Biology. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.ultrasmedbio.2018.10.033
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