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Microbubbles, nanodroplets and gas-stabilizing solid particles for ultrasound-mediated extravasation of unencapsulated drugs: an exposure parameter optimization study.

Abstract:

Ultrasound-induced cavitation has been proposed as a strategy to tackle the challenge of inadequate extravasation, penetration and distribution of therapeutics into tumours. Here, the ability of microbubbles, droplets and solid gas-trapping particles to facilitate mass transport and extravasation of a model therapeutic agent following ultrasound-induced cavitation is investigated. Significant extravasation and penetration depths on the order of millimetres are achieved with all three agents, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ultrasmedbio.2018.10.033

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Ultrasound in Medicine and Biology Journal website
Volume:
45
Issue:
4
Pages:
954-967
Publication date:
2019-01-14
Acceptance date:
2018-10-31
DOI:
EISSN:
1879-291X
ISSN:
0301-5629
Pmid:
30655109
Source identifiers:
963848
Language:
English
Keywords:
Pubs id:
pubs:963848
UUID:
uuid:9cd071d7-aac2-45e6-99a0-4ea4a6c881a5
Local pid:
pubs:963848
Deposit date:
2019-02-15

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