Journal article
5-hydroxymethylcytosine marks regions with reduced mutation frequency
- Abstract:
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CpG dinucleotides are the main mutational hot-spot in most cancers. The characteristic elevated C>T mutation rate in CpG sites has been related to 5-methylcytosine (5mC), an epigenetically modified base which resides in CpGs and plays a role in transcription silencing. In brain nearly a third of 5mCs have recently been found to exist in the form of 5-hydroxymethylcytosine (5hmC), yet the effect of 5hmC on mutational processes is still poorly understood. Here we show that 5hmC is associated...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
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(Accepted manuscript, pdf, 4.2MB)
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- Publisher copy:
- 10.7554/eLife.17082
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Authors
Funding
+ Ludwig Cancer Research
More from this funder
Funding agency for:
Kriaucionis, S
Grant:
BB/M001873/1
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Kriaucionis, S
Grant:
BB/M001873/1
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Tomkova, M
Grant:
EP/F500394/1
Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Publication date:
- 2016-05-01
- Acceptance date:
- 2016-05-03
- DOI:
- ISSN:
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2050-084X
- Source identifiers:
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619463
Item Description
- Keywords:
- Pubs id:
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pubs:619463
- UUID:
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uuid:9c3a3f6b-b7fd-4845-9cf7-60de1a2bbd71
- Local pid:
- pubs:619463
- Deposit date:
- 2016-05-06
Terms of use
- Copyright holder:
- Tomkova et al
- Copyright date:
- 2016
- Notes:
- Copyright Tomkova et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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