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5-hydroxymethylcytosine marks regions with reduced mutation frequency

Abstract:

CpG dinucleotides are the main mutational hot-spot in most cancers. The characteristic elevated C>T mutation rate in CpG sites has been related to 5-methylcytosine (5mC), an epigenetically modified base which resides in CpGs and plays a role in transcription silencing. In brain nearly a third of 5mCs have recently been found to exist in the form of 5-hydroxymethylcytosine (5hmC), yet the effect of 5hmC on mutational processes is still poorly understood. Here we show that 5hmC is associated...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.17082

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More from this funder
Funding agency for:
Schuster-Boeckler, P
More from this funder
Funding agency for:
Kriaucionis, S
Grant:
BB/M001873/1
More from this funder
Funding agency for:
Kriaucionis, S
Grant:
BB/M001873/1
More from this funder
Funding agency for:
Tomkova, M
Grant:
EP/F500394/1
More from this funder
Funding agency for:
Tomkova, M
Grant:
EP/F500394/1
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Publication date:
2016-05-01
Acceptance date:
2016-05-03
DOI:
ISSN:
2050-084X
Source identifiers:
619463
Keywords:
Pubs id:
pubs:619463
UUID:
uuid:9c3a3f6b-b7fd-4845-9cf7-60de1a2bbd71
Local pid:
pubs:619463
Deposit date:
2016-05-06

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