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Thesis

Investigating molecular mechanisms of Dali, an intergenic chromatin-associated lincRNA regulating genes locally and neural differentiation genome-wide

Abstract:

Recently, long non-coding RNAs (lncRNAs) emerged as important regulators of many cellular functions. Many nuclear lncRNAs regulate the expression of geomically proximal or overlapping protein coding genes. Less clear is whether intergenic lncRNAs can regulate transcription by modulating chromatin at genomically distant loci in an RNA-dependent manner. This thesis investigated molecular functions of Dali, an intergenic central nervous system expressed lncRNA conserved in therian ma...

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Institution:
University of Oxford
Division:
MSD
Research group:
Ponting group
Oxford college:
St Cross College
Role:
Author

Contributors

Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:9c296666-927c-4c53-b250-39e79643b0f8
Local pid:
ora:9420
Deposit date:
2014-11-27

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