Journal article icon

Journal article

Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica

Abstract:

Autoantibodies to aquaporin-4 (AQP4) are pathogenic in neuromyelitis optica spectrum disorder (NMOSD). However, it is not known which B cells are the major contributors to circulating AQP4 antibodies nor which conditions promote their generation. Our experiments showed CD19+CD27++CD38++ circulating ex vivo antibody-secreting cells did not produce AQP4 antibodies under several culture conditions. To question whether other cells in circulation were capable of AQP4 antibody production, B cells w...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1093/brain/awy010

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
Expand authors...
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
141
Issue:
4
Pages:
1063–1074
Publication date:
2018-02-13
Acceptance date:
2017-12-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Keywords:
Pubs id:
pubs:807410
UUID:
uuid:9c1f1a86-9389-4fe1-9edd-4c376aaa6e29
Local pid:
pubs:807410
Deposit date:
2017-12-01

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP