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High-content screening identifies a role for Na+ channels in insulin production

Abstract:

Insulin production is the central feature of functionally mature and differentiated pancreatic β-cells. Reduced insulin transcription and dedifferentiation have been implicated in type 2 diabetes, making drugs that could reverse these processes potentially useful. We have previously established ratiometric live-cell imaging tools to identify factors that increase insulin promoter activity and promote β-cell differentiation. Here, we present a single vector imaging tool with eGFP and mRFP, dri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsos.150306

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Institution:
University of Oxford
Oxford college:
Wolfson College
Role:
Author
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Publisher:
Royal Society Publisher's website
Journal:
Royal Society Open Science Journal website
Volume:
2
Issue:
12
Pages:
ARTN 150306
Publication date:
2015-12-01
Acceptance date:
2015-10-30
DOI:
EISSN:
2054-5703
Pmid:
27019722
Source identifiers:
606694
Language:
English
Keywords:
Pubs id:
pubs:606694
UUID:
uuid:9bf28324-cea6-4a6e-b854-a9bd84d47ee7
Local pid:
pubs:606694
Deposit date:
2017-10-02

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