Journal article
High-content screening identifies a role for Na+ channels in insulin production
- Abstract:
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Insulin production is the central feature of functionally mature and differentiated pancreatic β-cells. Reduced insulin transcription and dedifferentiation have been implicated in type 2 diabetes, making drugs that could reverse these processes potentially useful. We have previously established ratiometric live-cell imaging tools to identify factors that increase insulin promoter activity and promote β-cell differentiation. Here, we present a single vector imaging tool with eGFP and mRFP, dri...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.0MB)
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- Publisher copy:
- 10.1098/rsos.150306
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Royal Society Publisher's website
- Journal:
- Royal Society Open Science Journal website
- Volume:
- 2
- Issue:
- 12
- Pages:
- ARTN 150306
- Publication date:
- 2015-12-01
- Acceptance date:
- 2015-10-30
- DOI:
- EISSN:
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2054-5703
- Pmid:
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27019722
- Source identifiers:
-
606694
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:606694
- UUID:
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uuid:9bf28324-cea6-4a6e-b854-a9bd84d47ee7
- Local pid:
- pubs:606694
- Deposit date:
- 2017-10-02
Terms of use
- Copyright holder:
- Szabat et al
- Copyright date:
- 2015
- Notes:
- © 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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