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Increased central adiposity and decreased subcutaneous adipose tissue 11β‐hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance—A longitudinal cohort study

Abstract:

Objective and Context Increasing adiposity, ageing and tissue‐specific regeneration of cortisol through the activity of 11β‐hydroxysteroid dehydrogenase type 1 have been associated with deterioration in glucose tolerance. We undertook a longitudinal, prospective clinical study to determine if alterations in local glucocorticoid metabolism track with changes in glucose tolerance.

Design, Patients, and Measurements Sixty‐five overweight/obese individu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1111/cen.13939

Authors


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Role:
Author
ORCID:
0000-0003-1472-4117
More by this author
Role:
Author
ORCID:
0000-0003-0358-4745
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National Institute for Health Research More from this funder
Royal College of Physicians London More from this funder
European Research Council More from this funder
Irish Endocrine Society More from this funder
Publisher:
Wiley Publisher's website
Journal:
Clinical Endocrinology Journal website
Volume:
91
Issue:
1
Pages:
72-81
Publication date:
2019-01-22
Acceptance date:
2019-01-16
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
Pmid:
30667079
Source identifiers:
966057
Language:
English
Keywords:
Pubs id:
pubs:966057
UUID:
uuid:9aaa2172-d881-4218-bfc1-4f2ccf7bab77
Local pid:
pubs:966057
Deposit date:
2019-09-06

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