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Mechanistic studies on 2-oxoglutarate dependent oxygenases

Abstract:

The first identfied 2-oxoglutarate (2OG) dependent oxygenase was a collagen modifying enzyme in the work by Hutton et al. in 1967. Subsequent work has revealed that 2OG dependent oxygenases are a large family with diverse biological roles. With small molecule substrates, these enzymes catalyse a wide range of oxidative reactions, including those that form part of antibiotic biosynthetic pathways. The currently accepted consensus mechanism for catalysis by 2OG-dependent oxygenases ...

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Institution:
University of Oxford
Research group:
Prof. Christopher J. Schofield
Oxford college:
St Peter's College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemical Biology
Role:
Author

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Funding agency for:
Andrea Szollossi
Publication date:
2012
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:995b3390-4a81-41c7-af72-1423719261d5
Local pid:
ora:6974

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