Journal article
Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release
- Abstract:
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Somatostatin secretion from pancreatic islet δ-cells is stimulated by elevated glucose levels, but the underlying mechanisms have only partially been elucidated. Here we show that glucose-induced somatostatin secretion (GISS) involves both membrane potential-dependent and -independent pathways. Although glucose-induced electrical activity triggers somatostatin release, the sugar also stimulates GISS via a cAMP-dependent stimulation of CICR and exocytosis of somatostatin. The latter effect is ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.1MB)
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- Publisher copy:
- 10.1085/jgp.201912351
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Rockefeller University Press Publisher's website
- Journal:
- Journal of General Physiology Journal website
- Volume:
- 151
- Issue:
- 9
- Pages:
- 1094-1115
- Publication date:
- 2019-07-29
- Acceptance date:
- 2019-07-09
- DOI:
- EISSN:
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1540-7748
- ISSN:
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0022-1295
- Pmid:
-
31358556
- Source identifiers:
-
1038662
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1038662
- UUID:
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uuid:994835b8-0b86-4e41-b6f0-e4a677e0cfde
- Local pid:
- pubs:1038662
- Deposit date:
- 2019-10-04
Terms of use
- Copyright holder:
- Denwood et al.
- Copyright date:
- 2019
- Rights statement:
- © 2019 Denwood et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
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