Thesis
Role pf PPARalpha in the cardiac metabolic adaptation to chronic hypoxia
- Abstract:
-
The principal substrate used by the normal adult human heart is free fatty acids, the remainder being, predominantly,carbohydrate. During failure, the heart becomes less reliant on fatty acid metabolism, possibly as a result of tissue hypoxia. Therefore, understanding hypoxic adaptation may explain the metabolic changes that occur during the development of heart failure.As peroxisome proliferator activated receptor alpha (PPARα) modulates cardiac fatty acid metabolism, the work in this the...
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Authors
Contributors
+ Clarke, K
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:97e40889-8ae6-47db-867c-f1b020959a90
- Local pid:
- ora:7121
- Deposit date:
- 2013-07-30
Terms of use
- Copyright holder:
- Abd Jamil, A
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA.
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