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Comparing co-evolution methods and their application to template-free protein structure prediction

Abstract:

Motivation: Co-evolution methods have been used as contact predictors to identify pairs of residues that share spatial proximity. Such contact predictors have been compared in terms of the precision of their predictions, but there is no study that compares their usefulness to model generation.

Results: We compared eight different co-evolution methods for a set of ∼3500 proteins and found that metaPSICOV stage 2 produces, on average, the most precise predictions. Precision of all the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/bioinformatics/btw618

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Societies, Other & Subsidiary Companies
Department:
Kellogg College
Oxford college:
Kellogg College
Role:
Author
More from this funder
Funding agency for:
de Oliveira, S
Grant:
EP/G037280/1
More from this funder
Funding agency for:
Deane, C
Grant:
EP/G037280/1
Publisher:
Oxford University Press Publisher's website
Journal:
Bioinformatics Journal website
Volume:
33
Issue:
3
Pages:
373-381
Publication date:
2017-02-01
Acceptance date:
2016-09-22
DOI:
EISSN:
1460-2059
ISSN:
1367-4811
Source identifiers:
679822
Language:
English
Keywords:
Pubs id:
pubs:679822
UUID:
uuid:97dd2066-b353-4faa-a825-278778ab0ff7
Local pid:
pubs:679822
Deposit date:
2017-02-17

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