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Journal article

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses.

Abstract:

Identification of protective T cell responses against SARS-CoV-2 requires distinguishing people infected with SARS-CoV-2 from those with cross-reactive immunity to other coronaviruses. Here we show a range of T cell assays that differentially capture immune function to characterise SARS-CoV-2 responses. Strong ex vivo ELISpot and proliferation responses to multiple antigens (including M, NP and ORF3) are found in 168 PCR-confirmed SARS-CoV-2 infected volunteers, but are rare in 119 uninfected...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-21856-3

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Role:
Author
ORCID:
0000-0001-7774-7215
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Role:
Author
ORCID:
0000-0002-2426-3097
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Role:
Author
ORCID:
0000-0001-6751-3300
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Wellcome Trust More from this funder
John Fell Fund More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
12
Issue:
1
Article number:
2055
Publication date:
2021-04-06
Acceptance date:
2021-02-15
DOI:
EISSN:
2041-1723
Pmid:
33824342
Language:
English
Keywords:
Pubs id:
1170966
Local pid:
pubs:1170966
Deposit date:
2021-04-13

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