Journal article
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses.
- Abstract:
-
Identification of protective T cell responses against SARS-CoV-2 requires distinguishing people infected with SARS-CoV-2 from those with cross-reactive immunity to other coronaviruses. Here we show a range of T cell assays that differentially capture immune function to characterise SARS-CoV-2 responses. Strong ex vivo ELISpot and proliferation responses to multiple antigens (including M, NP and ORF3) are found in 168 PCR-confirmed SARS-CoV-2 infected volunteers, but are rare in 119 uninfected...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
John Fell Fund
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 12
- Issue:
- 1
- Article number:
- 2055
- Publication date:
- 2021-04-06
- Acceptance date:
- 2021-02-15
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
33824342
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1170966
- Local pid:
- pubs:1170966
- Deposit date:
- 2021-04-13
Terms of use
- Copyright holder:
- Ogbe et al.
- Copyright date:
- 2021
- Rights statement:
- ©2021 The Authors. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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