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Thesis

Regulated antagonism of immune suppressive molecules in tumours

Abstract:

Despite expressing antigens that can induce immune surveillance and immune eradication, tumours demonstrate the capacity to evade anti-tumour immunity. Recently, this has been attributed to the ability of tumours to induce a local immunosuppressed micro-environment, which is a major obstacle to successful natural and vaccine induced anti-tumour immunity. Soluble factors such as transforming growth factor beta (TGF&), and interleukin 10 (IL-10), released by cancer and stromal cells, ar...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Research group:
LWS
Oxford college:
Wolfson College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:95599708-58e8-4a35-92b9-4e31523556f3
Deposit date:
2014-10-30

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