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Cell-extrinsic autophagy in mature adipocytes regulates anti-inflammatory response to intestinal tissue injury through lipid mobilization

Abstract:

Autophagy is a critical cellular recycling pathway which is genetically linked to the development of intestinal inflammation in humans. Inflammation drives adipose tissue breakdown and provision of major nutrients such as free fatty acids (FFA). However, the effect of autophagy-mediated FFA release by adipocytes in immune-mediated inflammatory diseases remains unexplored.

In a mouse model of intestinal inflammation, we found that visceral adipocytes upregulate autophagy at peak inf...

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Publication status:
Published
Peer review status:
Not peer reviewed

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Publisher copy:
10.1101/2021.10.25.465200

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Oxford college:
St Hilda's College
Role:
Author
ORCID:
0000-0002-3415-3449
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Role:
Author
ORCID:
0000-0003-2809-9498
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
ORCID:
0000-0002-4211-3420
More by this author
Role:
Author
ORCID:
0000-0002-2664-9145
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Publisher:
Cold Spring Harbor Laboratory Publisher's website
Host title:
Cold Spring Harbor Laboratory
Publication date:
2021-10-26
DOI:
Language:
English
Keywords:
Pubs id:
1207471
Local pid:
pubs:1207471
Deposit date:
2021-11-05

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