Internet publication
Cell-extrinsic autophagy in mature adipocytes regulates anti-inflammatory response to intestinal tissue injury through lipid mobilization
- Abstract:
-
Autophagy is a critical cellular recycling pathway which is genetically linked to the development of intestinal inflammation in humans. Inflammation drives adipose tissue breakdown and provision of major nutrients such as free fatty acids (FFA). However, the effect of autophagy-mediated FFA release by adipocytes in immune-mediated inflammatory diseases remains unexplored.
In a mouse model of intestinal inflammation, we found that visceral adipocytes upregulate autophagy at peak inf...
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- Publication status:
- Published
- Peer review status:
- Not peer reviewed
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Bibliographic Details
- Publisher:
- Cold Spring Harbor Laboratory Publisher's website
- Host title:
- Cold Spring Harbor Laboratory
- Publication date:
- 2021-10-26
- DOI:
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1207471
- Local pid:
- pubs:1207471
- Deposit date:
- 2021-11-05
Terms of use
- Copyright holder:
- Richter et al.
- Copyright date:
- 2021
- Rights statement:
- The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
- Licence:
- CC Attribution (CC BY)
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