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Thesis

How G4 ligands enhance the innate immune response in BRCA1/2- deficient cells and tumours

Abstract:

G-quadruplex binding ligands, like pyridostatin, are known to cause DNA damage and eventually trigger apoptosis (Rodriguez et al., 2012; Zimmer et al., 2016). The stabilisation of G-quadruplexes causes replication fork stalling resulting in DNA damage accumulation and subsequent activation of DNA damage repair pathways such as homologous recombination (Rodriguez et al., 2012). However, tumours lacking BRCA1 and BRCA2 expression, and consequently abrogation of homologous recombination, will...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Research group:
Tarsounas lab
Oxford college:
St Cross College
Role:
Author, Author

Contributors

Role:
Supervisor
ORCID:
0000-0001-6241-7969
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-05-29

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