Thesis

G-quadruplex binding ligands, like pyridostatin, are known to cause DNA damage and eventually trigger apoptosis (Rodriguez et al., 2012; Zimmer et al., 2016). The stabilisation of G-quadruplexes causes replication fork stalling resulting in DNA damage accumulation and subsequent activation of DNA damage repair pathways such as homologous recombination (Rodriguez et al., 2012). However, tumours lacking BRCA1 and BRCA2 expression, and consequently abrogation of homologous recombination, will...