Journal article
Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity
- Abstract:
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Post-translational modification of proteins expands their structural and functional capabilities beyond those directly specified by the genetic code. However, the vast diversity of chemically-plausible (including unnatural but functionally relevant) side-chains is not readily accessible. We describe C(sp3)–C(sp3) bond-forming reactions on proteins under biocompatible conditions, which exploit unusual carbon free radical chemistry, and use them to form C–C bonds with altered side chains. We ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 295.2KB)
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- Publisher copy:
- 10.1126/science.aag1465
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Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Bower, B
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Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Journal website
- Publication date:
- 2016-09-01
- Acceptance date:
- 2016-09-12
- DOI:
- EISSN:
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1095-9203
- ISSN:
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1095-9203 and 0036-8075
- Pmid:
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27708059
- Source identifiers:
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703130
Item Description
- Keywords:
- Pubs id:
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pubs:703130
- UUID:
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uuid:9179e0bf-4fb4-4c67-bb52-742087c4be4d
- Local pid:
- pubs:703130
- Deposit date:
- 2017-07-08
Terms of use
- Copyright holder:
- American Association for the Advancement of Science
- Copyright date:
- 2016
- Notes:
- Copyright © 2016, American Association for the Advancement of Science
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