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Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Abstract:

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P=4.5x10(-8)-1.2x10(-43)). Using a n...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1002607

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Institution:
University of Oxford
Role:
Author
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National Human Genome Research Institute More from this funder
Canadian Institutes of Health Research More from this funder
Canadian Foundation for Innovation More from this funder
Fonds de la recherche en sante du Quebec More from this funder
Ministere du Developpement economique More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
8
Issue:
3
Article number:
e1002607
Publication date:
2012-01-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
322832

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