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Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum

Abstract:

In the hippocampal CA1 area, the GABAergic trilaminar cells have their axon distributed locally in three layers and also innervate the subiculum. Trilaminar cells have a high level of somato-dendritic muscarinic M2 acetylcholine receptor, lack somatostatin expression and their presynaptic inputs are enriched in mGluR8a. But the origin of their inputs and their behaviour-dependent activity remain to be characterised. Here we demonstrate that (1) GABAergic neurons with the molecular features of...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00429-020-02029-2

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Oxford college:
Brasenose College
Role:
Author
ORCID:
0000-0002-9942-4502
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0001-7569-4121
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
Publisher:
Springer Publisher's website
Journal:
Brain Structure and Function Journal website
Volume:
225
Pages:
705–734
Publication date:
2020-02-03
Acceptance date:
2020-01-16
DOI:
EISSN:
1863-2661
ISSN:
1863-2653
Pmid:
32016558
Language:
English
Keywords:
Pubs id:
1085529
Local pid:
pubs:1085529
Deposit date:
2020-02-24

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