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The S. aureus 4-oxalocrotonate tautomerase SAR1376 enhances immune responses when fused to several antigens

Abstract:

A persistent goal of vaccine development is the enhancement of the immunogenicity of antigens while maintaining safety. One strategy involves alteration of the presentation of the antigen by combining antigens with a multimeric scaffold. Multi-antigen vaccines are under development, and there are presently far more candidate antigens than antigen scaffolding strategies. This is potentially problematic, since prior immunity to a scaffold may inhibit immune responses to the antigen-scaffold com...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-017-01421-z

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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National Institute for Health Research More from this funder
James Martin School, University of Oxford More from this funder
More from this funder
Grant:
601783 (BELLEROPHON project
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
1745
Pages:
1-12
Publication date:
2017-05-11
Acceptance date:
2017-03-29
DOI:
ISSN:
2045-2322
Source identifiers:
700461
Pubs id:
pubs:700461
UUID:
uuid:90b92be8-82c5-4753-95e3-8756ace3185f
Local pid:
pubs:700461
Deposit date:
2017-06-14

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