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Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis

Abstract:

Many invasive bacterial diseases are caused by organisms that are ordinarily harmless components of the human microbiome. Effective interventions against these microbes require an understanding of the processes whereby symbiotic or commensal relationships transition into pathology. Here, we describe bacterial genome-wide association studies (GWAS) of Neisseria meningitidis, a common commensal of the human respiratory tract that is nevertheless a leading cause of meningitis and sepsis. An init...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1009992

Authors


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Role:
Author
ORCID:
0000-0002-0738-7557
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-9996-8107
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Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLOS Pathogens Journal website
Volume:
17
Issue:
10
Article number:
e1009992
Place of publication:
United States
Publication date:
2021-10-18
Acceptance date:
2021-09-29
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pmid:
34662348
Language:
English
Keywords:
Pubs id:
1206085
Local pid:
pubs:1206085
Deposit date:
2021-12-07

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