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Journal article

Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation.

Abstract:

AIMS: To determine whether post-infarction LV dysfunction is due to low energy availability or inefficient energy utilization, we compared energy metabolism in normal and failing hearts. We also studied whether improved coupling of glycolysis and glucose oxidation by knockout of malonyl CoA decarboxylase (MCD-KO) would have beneficial effects on LV function and efficiency. METHODS AND RESULTS: Male C57BL/6 mice were subjected to coronary artery ligation (CAL) or sham operation (SHAM) procedur...

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Publication status:
Published

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Publisher copy:
10.1093/cvr/cvt216

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Journal:
Cardiovascular research
Volume:
101
Issue:
1
Pages:
30-38
Publication date:
2014-01-01
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Source identifiers:
429309
Language:
English
Keywords:
Pubs id:
pubs:429309
UUID:
uuid:8ce8767a-2225-4e0f-ae2c-87221d2cc7c8
Local pid:
pubs:429309
Deposit date:
2013-11-16

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