Journal article
Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation.
- Abstract:
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AIMS: To determine whether post-infarction LV dysfunction is due to low energy availability or inefficient energy utilization, we compared energy metabolism in normal and failing hearts. We also studied whether improved coupling of glycolysis and glucose oxidation by knockout of malonyl CoA decarboxylase (MCD-KO) would have beneficial effects on LV function and efficiency. METHODS AND RESULTS: Male C57BL/6 mice were subjected to coronary artery ligation (CAL) or sham operation (SHAM) procedur...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/cvr/cvt216
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Authors
Bibliographic Details
- Journal:
- Cardiovascular research
- Volume:
- 101
- Issue:
- 1
- Pages:
- 30-38
- Publication date:
- 2014-01-01
- DOI:
- EISSN:
-
1755-3245
- ISSN:
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0008-6363
- Source identifiers:
-
429309
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:429309
- UUID:
-
uuid:8ce8767a-2225-4e0f-ae2c-87221d2cc7c8
- Local pid:
- pubs:429309
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2014
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