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Essential role of MCM proteins in premeiotic DNA replication

Abstract:

A critical event in eukaryotic DNA replication involves association of minichromosome maintenance (MCM2-7) proteins with origins, to form prereplicative complexes (pre-RCa) that are competent for initiation. The ability of mutants defective in MCM2-7 function to complete meiosis had suggested that pre-RC components could be irrelevant to premeiotic S phase. We show here that MCM2-7 proteins bind to chromatin in fission yeast cells preparing for meiosis and during premeiotic S phase in a manne...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
Role:
Author
Publisher:
The American Society for Cell Biology Publisher's website
Journal:
Molecular Biology of the Cell Journal website
Volume:
13
Issue:
2
Pages:
435-444
Publication date:
2002-02-05
ISSN:
1059-1524
URN:
uuid:8ca11d5f-26a0-497a-93a2-49bb89a42466
Local pid:
ora:1689

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