Thesis
Investigating the pathogenic effects of antibodies against the VGKC-complex and N-methyl-D-aspartate receptor in CNS disorders
- Abstract:
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Over the last few years, antibody-mediated disorders of the central nervous system (CNS) have been a rapidly expanding field in neurology. The antibodies bind to extracellular domains of proteins expressed in the CNS and impair neuronal function. Patients with limbic encephalitis, Morvan’s syndrome have antibodies that bind to the voltage gated potassium channel (VGKC)-complex proteins, LGI1 and CASPR2, while patients with antibodies to the NMDAR have more complex encephalopathies. Clinica...
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Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:8c117bc1-5e6e-4adc-8e5b-eefc2deff380
- Local pid:
- ora:8201
- Deposit date:
- 2014-03-14
Terms of use
- Copyright holder:
- Pettingill, P
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA.
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