Thesis
Selective permeabilisation of the blood-brain barrier at sites of metastasis.
- Abstract:
-
Over one in five cancer patients will develop brain metastases and prognosis remains poor. Effective chemotherapeutics for primary systemic tumours have limited access to brain metastases owing to the blood-brain barrier (BBB). The aim of this study was to develop a strategy for specifically permeabilising the BBB at sites of cerebral metastases.
Tumour necrosis factor was injected intravenously into mouse models of haematogenously induced brain metastasis. BBB permeability was ass...
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Authors
Contributors
+ Sibson, N
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
+ Anthony, D
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
+ Seymour, L
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Funding
+ Medical Research Council; Cancer Research UK
More from this funder
Funding agency for:
Connell, J
Grant:
C5255/A12678
G1000402)
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:8c027208-8ea6-4de4-be78-ccead5121509
- Local pid:
- ora:11561
- Deposit date:
- 2015-06-03
Terms of use
- Copyright holder:
- John Connell
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available in ORA
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