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Journal article

Ventricular SK2 upregulation following angiotensin II challenge: modulation by p21-activated kinase-1

Abstract:

Effects of hypertrophic challenge on small-conductance, Ca2+-activated K+(SK2) channel expression were explored in intact murine hearts, isolated ventricular myocytes and neonatal rat cardiomyocytes (NRCMs). An established experimental platform applied angiotensin II (Ang II) challenge in the presence and absence of reduced p21-activated kinase (PAK1) (PAK1cko vs. PAK1f/f, or shRNA-PAK1 interference) expression. SK2 current contributions were detected through their sensitivity to apamin block...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.yjmcc.2021.11.001

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Publisher:
Elsevier Publisher's website
Journal:
Journal of Molecular and Cellular Cardiology Journal website
Volume:
164
Pages:
110-125
Publication date:
2021-11-10
Acceptance date:
2021-11-03
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
Pmid:
34774547
Language:
English
Keywords:
Pubs id:
1210555
Local pid:
pubs:1210555
Deposit date:
2022-02-25

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