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Telomere length and metabolic syndrome traits: a Mendelian randomisation study

Abstract:

Observational studies have revealed associations between short leucocyte telomere length (LTL), a TL marker in somatic tissues and multiple Metabolic Syndrome (MetS) traits. Animal studies have supported these findings by showing that increased telomere attrition leads to adipose tissue dysfunction and insulin resistance. We investigated the associations between genetically instrumented LTL and MetS traits using Mendelian Randomisation (MR). Fifty-two independent variants identified at FDR<0....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/acel.13445

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0002-5979-9019
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Oxford college:
Wolfson College
Role:
Author
John Fell Fund More from this funder
Publisher:
Wiley Publisher's website
Journal:
Aging Cell Journal website
Volume:
20
Issue:
8
Article number:
e13445
Publication date:
2021-07-27
Acceptance date:
2021-07-09
DOI:
EISSN:
1474-9726
ISSN:
1474-9718
Language:
English
Keywords:
Pubs id:
1185547
Local pid:
pubs:1185547
Deposit date:
2021-07-09

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