Journal article
Telomere length and metabolic syndrome traits: a Mendelian randomisation study
- Abstract:
-
Observational studies have revealed associations between short leucocyte telomere length (LTL), a TL marker in somatic tissues and multiple Metabolic Syndrome (MetS) traits. Animal studies have supported these findings by showing that increased telomere attrition leads to adipose tissue dysfunction and insulin resistance. We investigated the associations between genetically instrumented LTL and MetS traits using Mendelian Randomisation (MR). Fifty-two independent variants identified at FDR<0....
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
John Fell Fund
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Aging Cell Journal website
- Volume:
- 20
- Issue:
- 8
- Article number:
- e13445
- Publication date:
- 2021-07-27
- Acceptance date:
- 2021-07-09
- DOI:
- EISSN:
-
1474-9726
- ISSN:
-
1474-9718
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1185547
- Local pid:
- pubs:1185547
- Deposit date:
- 2021-07-09
Terms of use
- Copyright holder:
- Loh et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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