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Journal article

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

Abstract:

Down syndrome, caused by trisomy of chromosome 21, is the single most common risk factor for early-onset Alzheimer's disease. Worldwide approximately 6 million people have Down syndrome, and all these individuals will develop the hallmark amyloid plaques and neurofibrillary tangles of Alzheimer's disease by the age of 40 and the vast majority will go on to develop dementia. Triplication of APP, a gene on chromosome 21, is sufficient to cause early-onset Alzheimer's disease in the absence of D...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awy159

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Experimental Psychology
Role:
Author
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Funding agency for:
Wiseman, F
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Funding agency for:
Wiseman, F
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Funding agency for:
Tybulewicz, V
Grant:
FC001194
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Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
141
Issue:
8
Pages:
2457–2474
Publication date:
2018-06-26
Acceptance date:
2018-04-18
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pmid:
29945247
Source identifiers:
859821
Language:
English
Keywords:
Pubs id:
pubs:859821
UUID:
uuid:88004332-2895-4933-88b7-0470348438fd
Local pid:
pubs:859821
Deposit date:
2018-08-17

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