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Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Abstract:

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5%, 14 with estimated allelic odds ratio >2); ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41588-018-0241-6

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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Grant:
AcceleratingMedicines Partnership-T2D,fundedbyU01DK105535,U01DK062370,
U01DK078616
Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
50
Pages:
1505–1513
Publication date:
2018-10-08
Acceptance date:
2018-08-10
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
905821
Pubs id:
pubs:905821
UUID:
uuid:85c6768f-5bc8-48b6-ae4b-149d23bd3fb7
Local pid:
pubs:905821
Deposit date:
2018-08-14

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