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Identification of common variants associated with human hippocampal and intracranial volumes.

Abstract:

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonan...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ng.2250

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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
44
Issue:
5
Pages:
552–561
Publication date:
2012-05-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
325674

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