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A transcriptionally distinct CXCL13+ CD103+ CD8+ T-cell population is associated with B-cell 2 recruitment and neoantigen load in human cancer

Abstract:

The chemokine CXCL13 mediates recruitment of B cells to tumors and is essential for the formation of tertiary lymphoid structures (TLS). TLS are thought to support antitumor immunity and are associated with improved prognosis. However, it remains unknown whether TLS are formed in response to the general inflammatory character of the tumor micro-environment, or rather, are induced by (neo-)antigen-specific adaptive immunity. We here report on the unexpected finding that the transforming g...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/2326-6066.CIR-18-0517

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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Immunology Research Journal website
Volume:
7
Issue:
5
Publication date:
2019-03-14
Acceptance date:
2019-01-09
DOI:
EISSN:
2326-6074
ISSN:
2326-6066
Source identifiers:
958160
Keywords:
Pubs id:
pubs:958160
UUID:
uuid:81521a75-8756-4c2d-943f-a59e6801498a
Local pid:
pubs:958160
Deposit date:
2019-01-09

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