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Journal article

Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

Abstract:

Haematopoietic stem cells (HSCs) are the founding cells of the adult haematopoietic system, born during ontogeny from a specialized subset of endothelium, the haemogenic endothelium (HE) via an endothelial-to-haematopoietic transition (EHT). Although recently imaged in real time, the underlying mechanism of EHT is still poorly understood. We have generated a Runx1 +23 enhancer-reporter transgenic mouse (23GFP) for the prospective isolation of HE throughout embryonic development. Here we perfo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms3924

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Institution:
University of Oxford
Division:
Research Services
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
4
Article number:
2924
Publication date:
2013-11-12
Acceptance date:
2013-12-11
DOI:
EISSN:
2041-1723
Source identifiers:
441589
Language:
English
Keywords:
UUID:
uuid:81426a3c-ce96-4a26-9fec-9957f355ca67
Local pid:
pubs:441589
Deposit date:
2014-10-01

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