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Thesis

The evaluation of the contribution of low frequency, intermediate penetrance sequence variants to the pathogenesis of Type 2 Diabetes

Abstract:

Genome wide association studies (GWAS) and their subsequent meta-analysis have identified a large number of susceptibility variants for Type 2 diabetes (T2D) risk. However, the familial aggregation seen in this disease is not yet fully explained. The sibling relative risk (λs) due to all known variants is ~1.104 which is well below the epidemiological estimates of λs of ~3.0. There has therefore been great interest in the potential role of variants that would have bee...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Research group:
McCarthy/Gloyn
Oxford college:
St Edmund Hall
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Jafar-Mohammadi, B
Grant:
08/0003677
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:809d4270-3a74-4fea-b696-2f619bfb7100
Local pid:
ora:7028
Deposit date:
2013-07-17

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