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Why clinical trial outcomes fail to translate into benefits for patients.

Abstract:

Clinical research should ultimately improve patient care. For this to be possible, trials must evaluate outcomes that genuinely reflect real-world settings and concerns. However, many trials continue to measure and report outcomes that fall short of this clear requirement. We highlight problems with trial outcomes that make evidence difficult or impossible to interpret and that undermine the translation of research into practice and policy. These complex issues include the use of surrogate, c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13063-017-1870-2

Authors


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Institution:
University of Oxford
Division:
Societies, Other & Subsidiary Companies
Department:
Kellogg College
Oxford college:
Kellogg College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Volume:
18
Issue:
1
Pages:
122
Publication date:
2017-03-01
Acceptance date:
2017-02-28
DOI:
ISSN:
1745-6215
Source identifiers:
686108
Language:
English
Keywords:
Pubs id:
pubs:686108
UUID:
uuid:7fd17c1d-597e-4e52-80da-5286bbdbb393
Local pid:
pubs:686108
Deposit date:
2017-03-27

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