Thesis
The mechanism of action of iminosugars as antiretrovirals
- Abstract:
-
Iminosugars are a class of molecules that resemble sugars but for the substitution of a nitrogen for the oxygen in the hemiacetal ring. Several iminosugars are inhibitors of cellular glycosidase enzymes in the N-linked glycan processing pathway. Iminosugars inhibiting endoplasmic reticulum (ER) α-glucosidases are known to be antiviral against a broad range of enveloped viruses including human immunodeficiency virus (HIV), hepatitis C virus, dengue virus and influenza virus. This a...
Expand abstract
Actions
Funding
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:7fc4ae01-bdec-49d0-afec-e0f3e9e8f41d
- Local pid:
- ora:10844
- Deposit date:
- 2015-04-09
Terms of use
- Copyright holder:
- Simon Spiro
- Copyright date:
- 2014
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record