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MITF-dependent phenotypic plasticity regulates proton-coupled transport and controls lineage resistance to acidotic stress

Abstract:

The lineage addiction oncogene, Microphthalmia-Associated Transcription Factor (MITF), mediates melanoma phenotypic plasticity – a pathophysiological process that underlies intratumoural heterogeneity, where melanoma cells interchangeably alter their phenotypes and transcriptomic gene signatures depending on the expression levels of MITF. This thesis characterised the presence and nature of MITF-dependent phenotypic plasticity in relation to melanoma resistance to acidotic stress. We show ...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Oxford college:
Wolfson College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Oxford college:
Magdalen College
Role:
Supervisor
Institution:
National Defense Medical Center
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Sub department:
Pathology Dunn School
Oxford college:
Queen's College
Role:
Examiner
Institution:
University of Iceland
Role:
Examiner
More from this funder
Programme:
The Ministry of Education Technologies Incubation Scholarship
Funding agency for:
Yang, O
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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