Thesis
Developing inhibitors of bromodomain-histone interactions
- Abstract:
-
Lysine acetylation is a widespread protein post-translational modification that influences diverse cellular processes. An association between acetylation of histone N-terminal tails and transcriptional activation has been recognised since the 1960s. However, it has only become apparent since 2000 that many of the effects of histone acetylation are mediated by proteins that bind to acetyl-lysine through a specialised acetyl-lysine recognition domain, the bromodomain. Small-molecule inhibito...
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Funding
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:7ee6647c-4ac7-41ba-9f15-dfd49de9f6c2
- Local pid:
- ora:8491
- Deposit date:
- 2014-05-30
Terms of use
- Copyright holder:
- Hewings, D
- Copyright date:
- 2014
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