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Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones

Abstract:
Catalytic asymmetric conjugate addition reactions of alkylzirconium species to acyclic enones are reported. The alkylzirconium nucleophiles are generated in situ by hydrozirconation of alkenes with the Schwartz reagent. The reaction proceeds under mild and convenient conditions. A variety of functionalized nucleophiles can be used, and the method tolerates some variation in enone scope. The method uses a new chiral nonracemic phosphoramidite ligand in a complex with copper triflate.
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
Engineering and Physical Sciences Research Council More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Organic Letters
Volume:
17
Issue:
4
Pages:
912–915
Publication date:
2015-01-29
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
Language:
English
UUID:
uuid:7e591d5d-7826-4e19-81fc-c164e69502a0
Deposit date:
2015-09-18

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