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Distinct HLA associations of LGI1 and CASPR2-antibody diseases

Abstract:

The recent biochemical distinction between antibodies against leucine-rich, glioma-inactivated-1 (LGI1), contactin-associated protein-2 (CASPR2) and intracellular epitopes of voltage-gated potassium-channels (VGKCs) demands aetiological explanations. Given established associations between human leucocyte antigen (HLA) alleles and adverse drug reactions, and our clinical observation of frequent adverse drugs reactions in patients with LGI1 antibodies, we compared HLA alleles between healthy co...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awy109

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Varley, J
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Funding agency for:
Knight, JC
Grant:
Investigator Award (204969/Z/16/Z
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Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
141
Issue:
8
Pages:
2263–2271
Publication date:
2018-05-18
Acceptance date:
2018-02-09
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Keywords:
Pubs id:
pubs:824274
UUID:
uuid:7e16ed5b-bca2-4823-b84e-0207490e5515
Local pid:
pubs:824274
Deposit date:
2018-02-13

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