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Thesis

Investigating the role of the endocannabinoid system and gut-microbiome in psychotic and severe mental illness: a focus on negative symptoms

Abstract:

Negative symptoms, such as anhedonia and amotivation, represent unmet therapeutic needs and key determinants of functional loss in severe mental illness. Albeit traditionally considered a unique feature of schizophrenia, anhedonia and amotivation manifest outside the psychotic spectrum, where they are equally debilitating and difficult to treat. A number of clinical trials using newly developed compounds or re-repurposing existing drugs have tried to treat negative symptoms without succes...

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Division:
MSD
Department:
Psychiatry
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0002-4972-8786
Role:
Supervisor
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Programme:
Oxford - MRC DTP –St John’s College – Clarendon Studentship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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