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Journal article

A noninvasive comparison study between human gliomas with IDH1 and IDH2 mutations by MR spectroscopy

Abstract:

The oncogenes that are expressed in gliomas reprogram particular pathways of glucose, amino acids, and fatty acid metabolism. Mutations in isocitrate dehydrogenase genes (IDH1/2) in diffuse gliomas are associated with abnormally high levels of 2-hydroxyglutarate (2-HG) levels. The aim of this study was to determine whether metabolic reprogramming associated with IDH mutant gliomas leads to additional 1H MRS-detectable differences between IDH1 and IDH2 mutations, and to identify ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3390/metabo9020035

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0001-8078-4471
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0003-2360-9786
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Publisher:
MDPI Publisher's website
Journal:
Metabolites Journal website
Volume:
9
Issue:
2
Publication date:
2019-02-20
Acceptance date:
2019-02-15
DOI:
EISSN:
2218-1989
ISSN:
2218-1989
Pmid:
30791611
Source identifiers:
976311
Language:
English
Keywords:
Pubs id:
pubs:976311
UUID:
uuid:7c9ff358-3273-4d13-9159-b35391ac0781
Local pid:
pubs:976311
Deposit date:
2019-03-12

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