Journal article
Clinically actionable mutation profiles in patients with cancer identified by whole-genome sequencing
- Abstract:
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Next-generation sequencing (NGS) efforts have established catalogs of mutations relevant to cancer development. However, the clinical utility of this information remains largely unexplored. Here, we present the results of the first eight patients recruited into a clinical whole-genome sequencing (WGS) program in the United Kingdom. We performed PCR-free WGS of fresh frozen tumors and germline DNA at 75× and 30×, respectively, using the HiSeq2500 HTv4. Subtracted tumor VCFs and paired germline...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
National Institute for Health Research
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Bibliographic Details
- Publisher:
- Cold Spring Harbor Laboratory Press Publisher's website
- Journal:
- Cold Spring Harbor Molecular Case Studies Journal website
- Volume:
- 4
- Issue:
- 2
- Article number:
- a002279
- Publication date:
- 2018-04-02
- Acceptance date:
- 2018-02-09
- DOI:
- ISSN:
-
2373-2873
Item Description
- Keywords:
- Pubs id:
-
pubs:825452
- UUID:
-
uuid:7b4a3e84-0cef-44bc-b268-78161b2ff53a
- Local pid:
- pubs:825452
- Source identifiers:
-
825452
- Deposit date:
- 2018-02-20
Terms of use
- Copyright holder:
- Schuh et al
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 Schuh et al.; Published by Cold Spring Harbor Laboratory Press
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License, which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited.
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