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Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Abstract:

Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-020-19366-9

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Role:
Author
ORCID:
0000-0002-5668-2368
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Journal:
Nature communications
Volume:
12
Issue:
1
Pages:
24-
Publication date:
2021-01-05
Acceptance date:
2020-09-22
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
33402679

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