Journal article
Heterobiaryl synthesis by contractive C-C coupling via P(V) intermediates
- Abstract:
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Heterobiaryls composed of pyridine and diazine rings are key components of pharmaceuticals and are often central to pharmacological function. We present an alternative approach to metal-catalyzed cross-coupling to make heterobiaryls using contractive phosphorus C–C couplings, also termed phosphorus ligand coupling reactions. The process starts by regioselective phosphorus substitution of the C–H bonds para to nitrogen in two successive heterocycles; ligand coupling is then triggered via acidi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 578.1KB)
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- Publisher copy:
- 10.1126/science.aas8961
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Authors
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Journal website
- Volume:
- 362
- Issue:
- 6416
- Pages:
- 799-804
- Publication date:
- 2018-11-16
- Acceptance date:
- 2018-09-25
- DOI:
- EISSN:
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1095-9203
- ISSN:
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0036-8075
- Pmid:
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30442804
- Source identifiers:
-
943986
Item Description
- Language:
- English
- Pubs id:
-
pubs:943986
- UUID:
-
uuid:7acd2824-ee4c-43ab-8a50-bb9989a6f665
- Local pid:
- pubs:943986
- Deposit date:
- 2018-12-28
Terms of use
- Copyright holder:
- Hilton et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 The Authors, some rights reserved. This is the accepted manuscript version of the article. The final version is available online from the American Association for the Advancement of Science at: 10.1126/science.aas8961
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