Thesis
The role of IGF-1R signaling in the DNA damage response of prostate cancer
- Abstract:
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The type 1 insulin like growth factor receptor (IGF-1R) is a cell surface receptor that mediates proliferation and cell survival. The aim of this project was to explore the contribution of the IGF-1R to the DNA damage response in human prostate cancer cells. Previous work from our group showed IGF-1R to be over expressed in prostate cancer. Furthermore, IGF-1R depletion enhances sensitivity of prostate cancer cells to DNA damaging agents, and IGF-1R depletion or inhibition delays DSB re...
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Funding
Bibliographic Details
- Publication date:
- 2013-03-01
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:78bb4539-9873-40d6-84e1-38187e58f585
- Deposit date:
- 2016-11-15
Terms of use
- Copyright holder:
- Lodhia, K
- Copyright date:
- 2013
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